FIELD: biotechnology, medicine, molecular biology, genetic engineering, immunology. SUBSTANCE: invention proposes recombinant plasmid DNA pBMC-nef(A)m-1 that comprises gene nef of human immunodeficiency virus type I, subtype A, where in its sequence of nucleotides in codons with prevailing adenine and/or thymine bases adenine and/or thymine are replaced partially for guanine and/or cytosine. Plasmid provides the expression of protein NEF and can be used for immunization against human immunodeficiency virus. EFFECT: valuable biological and medicinal properties of plasmid DNA. 1 tbl, 3 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT PLASMID DNA PBMC-RT(A)M-1 USED FOR EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS REVERSE TRANSCRIPTASE (RT)IN HIGHER EUCARYOTIC CELLS | 2003 |
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|
RU2241752C1 |
| RECOMBINANT PLASMID DNA pBMC-RT(A)-hum FOR EXPRESSING PROTEIN OF REVERSE TRANSCRIPTASE OF HUMAN IMMUNODEFICIENCY VIRUS | 2006 |
|
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| pBMC-gp140(A)-hum EXPRESSION PLASMA DNA | 2006 |
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| EXPRESSIVE PLASMID DNA p-BMC-gag (A)-HUM FOR EXPRESSION OF PROTEIN p55 HJV-1 IN EUKARYOTE CELLS | 2006 |
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| RECOMBINANT PLASMID DNA PCDNA-TCI PROVIDING EXPRESSION OF ARTIFICIAL GENE TCI IN EUCARYOTIC CELLS AND RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA ENTERITIDIS E-23 PC-DNA-TCI AS CANDIDATE FOR CONSTRUCTION OF LIVE DNA-VACCINE AGAINST HUMAN IMMUNODEFICIENCY VIRUS | 2003 |
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RU2248396C2 |
| SELF-REPLICATING RECOMBINANT VECTOR EXPRESSING HIV REGULATORY PROTEINS, METHOD FOR IT PREPARING, DNA-BASE VACCINE CONTAINING INDICATED VECTOR FOR IMMUNIZATION AGAINST HIV, METHOD FOR HIV TREATMENT OR PROPHYLAXIS | 1999 |
|
RU2232815C2 |
| POLYPEPTIDE E117 DESIGNED FOR ANTIBODY ASSAY TO THE HUMAN IMMUNODEFICIENCY VIRUS OF THE FIRST TYPE, DNA FRAGMENT HE117 ENCODING POLYPEPTIDE E117, RECOMBINANT PLASMID DNA PHE117 ENCODING POLYPEPTIDE E117, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE E117 | 1992 |
|
RU2043413C1 |
