FIELD: biotechnology, medicine, genetic engineering, immunology.
SUBSTANCE: invention proposes plasmid DNA pBMC-gag(A)mod. Plasmid comprises gene encoding the protein gag in human immunodeficiency virus type 1, subtype A. In nucleotides sequence of this gene adenine and/or thymine in codons with prevalence of adenine and/or thymine are replaced partially for guanine and/or cytosine. Plasmid provides high level of protein gag expression of human immunodeficiency virus in eucaryotic cells. The proposed plasmid can be used for immunization against human immunodeficiency virus type 1 (HIV-1), subtype A.
EFFECT: valuable biological and medicinal properties of plasmid.
3 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| EXPRESSIVE PLASMID DNA p-BMC-gag (A)-HUM FOR EXPRESSION OF PROTEIN p55 HJV-1 IN EUKARYOTE CELLS | 2006 |
|
RU2345138C2 |
| RECOMBINANT PLASMID DNA PBMC-QP120(A)M-1 FOR IMMUNIZATION AGAINST HUMAN IMMUNODEFICIENCY VIRUS | 2003 |
|
RU2227161C1 |
| RECOMBINANT PLASMID DNA PBMC-RT(A)M-1 USED FOR EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS REVERSE TRANSCRIPTASE (RT)IN HIGHER EUCARYOTIC CELLS | 2003 |
|
RU2238977C1 |
| RECOMBINANT PLASMID DNA pBMC-nef(A)m-1 EXPRESSING PROTEIN NEF OF HUMAN IMMUNODEFICIENCY VIRUS TYPE I VIRUS IN EUCARYOTIC CELLS | 2003 |
|
RU2229518C1 |
| pBMC-gp140(A)-hum EXPRESSION PLASMA DNA | 2006 |
|
RU2346044C2 |
| EXPRESSION PLASMID DNA pBMC - nef (A)-hum | 2006 |
|
RU2335540C1 |
| RECOMBINANT PLASMID DNA pBMC-RT(A)-hum FOR EXPRESSING PROTEIN OF REVERSE TRANSCRIPTASE OF HUMAN IMMUNODEFICIENCY VIRUS | 2006 |
|
RU2355764C2 |
| FRAGMENT HTLV-I/II OF GENE GAG, RECOMBINANT PLASMID DNA PATLG 579, STRAIN OF BACTERIUM ESCHERICHIA COLI HB 101/PATLG 579 - PRODUCER OF POLYPEPTIDE G 579 | 1998 |
|
RU2149876C1 |
| POLYPEPTIDE G103 DESIGNED FOR ANTIBODY ASSAY TO HUMAN IMMUNODEFICIENCY VIRUS OF THE FIRST TYPE, DNA FRAGMENT HG103 ENCODING POLYPEPTIDE G103, RECOMBINANT PLASMID DNA PHG103 ENCODING POLYPEPTIDE G103, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE G103 | 1992 |
|
RU2043414C1 |
| POLYPEPTIDE E117 DESIGNED FOR ANTIBODY ASSAY TO THE HUMAN IMMUNODEFICIENCY VIRUS OF THE FIRST TYPE, DNA FRAGMENT HE117 ENCODING POLYPEPTIDE E117, RECOMBINANT PLASMID DNA PHE117 ENCODING POLYPEPTIDE E117, STRAIN OF BACTERIUM ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE E117 | 1992 |
|
RU2043413C1 |
