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2 230 782

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IPC

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Application

2003106841/13, 2003-03-14

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Start date

2003-03-14

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Actual filing date

2003-03-14

(45)

Published

2004-06-20

(72)

Inventor

Borisova V.N.Budanov M.V.Jakovleva I.M.Mel'Nikov V.A.Agafonov M.O.Ter-Avanesjan M.D.

(73)

Holder

Zakrytoe Aktsionernoe Obshchestvo Nauchno-Proizvodstvennaja Kompanija

TRANSFORMED YEAST STRAIN PICHIA ANGUSTA AS PRODUCER OF RECOMBINANT SURFACE ANTIGEN HBSAG/AYW OF HEPATITIS B VIRUS Russian patent published in 2004 - IPC

Abstract RU 2230782 C1

FIELD: biotechnology, genetic engineering, microbiology.

SUBSTANCE: invention proposes the yeast strain Pichia angusta VKM Y-2924D as a producer of recombinant surface antigen of hepatitis B virus of subtype yaw. The strain has been generated by insertion the DNA sequence into yeast cells that encodes HbsAg/ayw and fused with gene MOX promoter and gene TRP3. The strain provides high yield of recombinant antigen of hepatitis B virus serotype yaw using the more simple methods used for preparing cultures with high cell density. Invention can be used for microbiological method for preparing the recombinant surface antigen of hepatitis B virus.

EFFECT: valuable biological properties of strain.

8 ex

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RU 2 230 782 C1

Authors

Borisova V.N.

Budanov M.V.

Jakovleva I.M.

Mel'Nikov V.A.

Agafonov M.O.

Ter-Avanesjan M.D.

Dates

2004-06-20—Published

2003-03-14—Filed