NEW NUCLEOSIDE AND OLIGONUCLEOTIDE ANALOGUES Russian patent published in 2004 - IPC

Abstract RU 2233844 C2

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to nucleoside analogues of the formula (1) wherein R¹ represents hydrogen atom (H) or hydroxyl-protected group; R² represents hydrogen atom (H), hydroxyl-protective group, phosphoric acid group, phosphoric acid-protected group or group of the formula P(R³)R⁴ wherein R and R⁴ are similar or different and represent hydroxyl group, hydroxyl-protected, alkoxy-group, alkylthio-group, cyanoalkoxy-group, amino-group substituted with alkyl group; A represents alkylene group comprising from 1 to 4 carbon atoms; B represents substituted purine-9-yl group or substituted 2-oxopyrimidine-1-yl group comprising at least one substituent taken among hydroxyl group, hydroxyl-protected group, amino-group, amino-protected group, alkyl group. Also, invention relates to oligonucleotide analogues comprising one or more structures of the formula (2) wherein A and B have values indicated for the formula (1). Oligonucleotide analogues or their pharmacologically acceptable salts can be used as medicinal preparations eliciting nonsense-activity or antigenic activity.

EFFECT: valuable medicinal properties of compounds.

12 cl, 6 tbl, 48 ex

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RU 2 233 844 C2

Authors

Kaneko Masakatsu

Morita Kodzi

Imanisi Takesi

Dates

2004-08-10—Published

2000-02-10—Filed