FIELD: biotechnology, biochemistry.
SUBSTANCE: method for stereoselective reduction of racemic 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthaleon involves interaction of indicated tetralone with microorganism or enzyme. Method involves using microorganism taken among the group consisting of Hansenula polymorpha ATCC № 26012, Hansenula polymorpha ATCC № 74449, Absidia coerulea ATCC № 20137, Geotrichum candidum ATCC № 34614, Geotrichum candidum ATCC № 62401, Mortierella isabellina ATCC № 42613, Mortierella isbellina ATCC № 38063, Mortierella vinacea ATCC № 09515, Penicillium notatum ATCC № 36740, Blastoschizomyces capitatus ATCC № 28575, Monosporium olivaceum v. major ATCC № 36300, Aureobasidium pullulans ATCC № 16623, Debaryomyces polymorphus ATCC № 20280, Saccharomyces cerevisiae ATCC № 15248, Candida schatavii ATCC № 24409, Pichia fabianii ATCC № 16755 and Streptomyces rimosus ss. Rimosus ATCC № 10970. Method elicits stereoselectivity and provides high yield of product that can be used in synthesis of sertraline.
EFFECT: improved reducing method.
35 cl, 3 tbl, 3 ex
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