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2 215 038

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IPC

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Application

2001135526/13, 2001-12-29

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Start date

2001-12-29

(22)

Actual filing date

2001-12-29

(45)

Published

2003-10-27

(72)

Inventor

Andrjushina V.A.Vojshvillo N.E.Skrjabin K.G.Stytsenko T.S.Savinova T.S.Sazonova A.S.

(73)

Holder

Andrjushina Valentina AleksandrovnaVojshvillo Natalija Evgen'EvnaSkrjabin Konstantin GeorgievichStytsenko Tat'Jana SemenovnaSavinova Tat'Jana StepanovnaSazonova Anastasija SergeevnaTsentr Ran

STRAIN PIMELOBACTER SIMPLEX ELICITING STEROID-1,2-DEHYDROGENASE ACTIVITY Russian patent published in 2003 - IPC

Abstract RU 2215038 C2

FIELD: biotechnology, steroids, biochemistry. SUBSTANCE: invention relates to preparing Δ^1,2-corticosteroids by microbiological method. The strain Pimelobacter simplex VKPM Ac-1632 is able to introduce 1,2-double bond into Δ⁴-3-ketosteroids or into Δ⁵-3β-hydroxysteroids of pregnane order with formation of cross-coupled system in ring A of steroid molecule. The strain Pimelobacter simplex VKPM Ac-1632 provides carrying out the transformation with charge of the parent steroid up to 6 g/l by conversion to the end product up to 99% and without usage of solubilizing agents. The strain Pimelobacter simplex VKPM Ac-1632 shows broad specificity and perspective catalyst of processes for modification of steroids. EFFECT: enhanced effectiveness and valuable biochemical properties of strain. 1 tbl 1 ex

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RU 2 215 038 C2

Authors

Andrjushina V.A.

Vojshvillo N.E.

Skrjabin K.G.

Stytsenko T.S.

Savinova T.S.

Sazonova A.S.

Dates

2003-10-27—Published

2001-12-29—Filed