OLIGOPEPTIDE ELICITING ACTIVITY IN ATTACHMENT, SPREADING AND DETACHMENT OF CELLS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2004 - IPC

FIELD: biotechnology, chemistry of peptides, pharmacy.

SUBSTANCE: invention relates to peptides eliciting activity in attachment, spreading and detachment of cells and can be used in study of activity in attachment cells mediated with different proteins of extracellular matrix, for development of peptides, adhesion and in curative aims also. Oligopeptides stimulate activity in attachment of cells by interaction with integrin α3β1 as functional cellular receptor and comprise aspartic acid and isoleucine that are necessary for activity in attachment and detachment of cells. Pharmaceutical composition containing effective amount of oligopeptide is used for healing wounds, tissue regeneration and inhibition of metastasis. Invention provides preparing oligopeptide comprising conservative amino acid sequence DI that is necessary for regulation of cellular adhesion.

EFFECT: valuable biological and medicinal properties of composition.

8 cl, 15 dwg, 3 ex