FIELD: molecular biology, medicine, pharmacy.
SUBSTANCE: invention shows that polycationic compositions non/lipid : DNA are stable to spraying-induced degradation and they are significantly more specific and effective as compared with lipid-base compositions in transfection of respiratory way tissues in vivo. Polyethyleneimine compositions are about 10 times more effective than lipid-base known compositions in delivery of jet spraying agent in vivo. Polyethyleneimine-base aerosol compositions are effective for genetic therapy through respiratory ways.
EFFECT: improved and valuable properties of compositions.
24 cl, 17 dwg, 33 ex
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