FORMULA FOR INTRODUCING RNA Russian patent published in 2023 - IPC A61K31/7105 A61K47/59 C12N15/87 A61P31/12 

FIELD: pharmaceuticals; medicine.

SUBSTANCE: 1 object represents pharmaceutical composition for intramuscular injection, which includes an active ingredient, which is single-stranded self-replicating RNA coding for a peptide or protein containing an antigen or epitope, wherein the said self-replicating RNA is derived from Venezuelan equine encephalitis virus (VEEV) or from Semliki Forest virus (SFV), and polyethyleneimine, wherein the said self-replicating RNA and polyethyleneimine are in polyplex particles, and the molar ratio of the number of nitrogen atoms (N) in polyethyleneimine to the number of phosphorus atoms (P) in single-stranded RNA (N:P ratio) is from 2.0 to 15.0. 2 object — a method of inducing an immune response, including the stage of administering the composition.

EFFECT: inducing an immune response when administered intramuscularly using RNA and polyethyleneimine polyplexes containing single-stranded self-replicating RNA derived from VEEV or from SFV.

36 cl, 38 dwg, 7 tbl, 26 ex