FIELD: biology.
SUBSTANCE: present invention relates to the use of compositions containing polyplex compositions for delivery of RNA to target organs or target cells after parenteral administration, in particular after intramuscular administration. More specifically, the present invention relates to a method for the safe administration of RNA of the self-replicating RNA type, in particular by intramuscular injection. More specifically, the compositions contain polyplex particles of single-stranded RNA and polyalkyleneimine. The RNA can encode a protein of interest, such as a pharmaceutically active protein.
EFFECT: RNA administration.
16 cl, 34 dwg, 7 tbl, 22 ex
| Title | Year | Author | Number |
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