FIELD: medicine, infectious diseases.
SUBSTANCE: invention relates to antigenic composition and a method for detection of antibodies raised to Treponema pallidum in syphilis diagnosis. The antigenic composition comprises synthetic cardiolipin and synthetic lecithin (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) and can comprise additionally cholesterol and alcohol. The antigenic composition can be used as an immunoreagent in immune analysis for detection of antibodies associated with the T. pallidum infection. The proposed method shows the enhanced sensitivity and specificity with respect to the T. pallidum infection.
EFFECT: improved detecting method.
23 cl, 8 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR CONTROLLING CLINICAL EFFECTIVENESS IN SYPHILIS | 2011 |
|
RU2474820C2 |
| STABILIZED CARDIOLYPINE ANTIGEN FOR THE REACTION OF MICROPRECIPITATION WITH SYPHILISIS DIAGNOSIS AND THE METHOD OF ITS RECEPTION | 2016 |
|
RU2633087C2 |
| MEANS OF NONSPECIFIC SERODIAGNOSIS OF SYPHILIS SERONEGATIVE FORMS | 2010 |
|
RU2442536C2 |
| SYPHILIS DIAGNOSTIC TECHNIQUE BY SIMULTANEOUS DETECTION OF REAGINIC AND TREPONEMA-SPECIFIC T PALLIDUM ANTIBODIES ON MICROSCOPE ALDEHYDE SLIDES | 2009 |
|
RU2394496C1 |
| METHOD FOR PREPARING REFERENCE SERUM FOR ANTICARDIOLIPIN ANTIBODIES DIAGNOSIS IN QUANTITATIVE MICROPRECIPITIN TEST FOR SYPHILIS | 2009 |
|
RU2399383C1 |
| DIAGNOSTIC TEST SYSTEM IN IMMUNOCHIP FORMAT AND DIFFERENTIAL SERUM DIAGNOSTICS OF SYPHILIS | 2009 |
|
RU2397178C1 |
| METHOD FOR IN VITRO DIAGNOSING FALSE POSITIVE RESPONSES CAUSED BY ANTIPHOSPHOLIPID SYNDROME IN TESTING FOR SYPHILIS | 2001 |
|
RU2206094C1 |
| METHOD FOR SERODIAGNOSTICS OF EARLY NEUROSYPHILIS | 2001 |
|
RU2205409C2 |
| SYPHILIS DIAGNOSTIC TECHNIQUE WITH USING METHOD OF DIRECT PROTEOMIC BLOOD SERUM PROFILING | 2008 |
|
RU2381505C1 |
| METHOD FOR DIAGNOSTICS OF SYPHILIS (VARIANTS) | 1999 |
|
RU2200327C2 |
