METHOD FOR PREPARING REFERENCE SERUM FOR ANTICARDIOLIPIN ANTIBODIES DIAGNOSIS IN QUANTITATIVE MICROPRECIPITIN TEST FOR SYPHILIS Russian patent published in 2010 - IPC A61K39/40 A61K39/05 G01N33/571 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to preparing diagnostic products. The method is implemented by intratesticular infections of rabbits producers of 3.0-3.5 kg with pathogenic Nichols strain T. Pallidum pallidum. 7-8 days after the infection, the animals are additionally twice intravenously immunised with purified treponema proteins ("ОПТ"-antigen) recovered from "КСТ"-antigen of cultural Treponema Palladium in dosage 0.023 g, every 7-8 days. It is followed with exsanguination 30 days after the infection. The prepared serums are analysed for anticardiolipin antibodies titre in quantitative cardiolipin antigen microprecipitation test.

EFFECT: method allows increasing anticardiolipin antibodies titre, standardising a procedure of quantitative cardiolipin microprecipitation test for syphilis, and halving the findings analysis time.

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