FIELD: biotechnology, genetic engineering, molecular biology.
SUBSTANCE: invention proposes recombinant DNA pcDNA-TCI that has molecular mass 4.3 x 103 kDa and size 6 657 nucleotide pairs. The proposed recombinant plasmid DNA provides expression of artificial gene TCI comprising cytotoxic T-cellular epitopes of HIV-1 in eucaryotic cells. Also, invention proposes recombinant attenuated strain of bacterium Salmonella enteritidis E-23 pcDNA-TCI. The proposed strain is obtained by genetic transformation of the strain Salmonella enteritidis E-23 with plasmid pcDNA-TCI. The strain provides delivery DNA-vaccine in eucaryotic cells as the recombinant plasmid DNA pcDNA-TCI. Proposed groups of inventions provide inducing the expressed specific humoral and cellular immune response to HIV-1 in body. Proposed group of inventions can be used in medicine and virology for construction of live DNA-vaccine against HIV-1.
EFFECT: valuable biological and medicinal properties of strain and vaccine.
2 cl, 3 dwg, 3 tbl, 5 ex
| Title |
Year |
Author |
Number |
| SUPPOSITORY FOR IMMUNOPROPHYLAXIS OF VIRAL INFECTIONS |
2004 |
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- Nekrasova Nadezhda Aleksandrovna
- Veremejko Tat'Jana Aleksandrovna
- Levagina Galina Mikhajlovna
- Tereshchenko Tamara Anatol'Evna
- Malakhova Tat'Jana Valer'Evna
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- Masycheva Valentina Ivanovna
- Ignat'Ev Georgij Mikhajlovich
- Agafonov Aleksandr Petrovich
|
RU2296560C2 |
| RECOMBINANT VACCINE AGAINST HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 |
2006 |
- Karpenko Larisa Ivanovna
- Bazhan Sergej Ivanovich
- Lebedev Leonid Rudol'Fovich
- Nekrasova Nadezhda Aleksandrovna
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|
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2012 |
- Antonets Denis Viktorovich
- Bazhan Sergej Ivanovich
- Il'Ichev Aleksandr Alekseevich
- Karpenko Larisa Ivanovna
- Borobova Elena Aleksandrovna
- Starostina Ekaterina Vladimirovna
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- Oreshkova Svetlana Fedorovna
|
RU2522830C2 |
| RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA ENTERIDITIS E-23/PGEX-2T-TBI AS CANDIDATE FOR CONSTRUCTION OF LIVE VACCINE AGAINST HUMAN IMMUNODEFICIENCY VIRUS |
2002 |
- Karpenko L.I.
- Nekrasova N.A.
- Ignat'Ev G.M.
- Il'Ichev A.A.
- Bojchenko M.N.
- Vorob'Ev A.A.
|
RU2237089C2 |
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2017 |
- Antonets Denis Viktorovich
- Borobova Elena Aleksandrovna
- Ilichev Aleksandr Alekseevich
- Karpenko Larisa Ivanovna
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- Smirnova Olga Yurevna
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- Bazhan Sergej Ivanovich
|
RU2650872C1 |
| RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA TYPHIMURIUM T10/PKHBC AS PRODUCER OF HEPATITIS B VIRUS CORE ANTIGEN |
2002 |
- Karpenko L.I.
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- Ignat'Ev G.M.
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- Bojchenko M.N.
- Vorob'Ev A.A.
|
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2001 |
- Shchelkunov S.N.
- Rjazankin I.A.
- Ageenko V.A.
- Ignat'Ev G.M.
- Babkin I.V.
|
RU2194075C2 |
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2004 |
- Gintsburg Aleksandr Leonidovich
- Karjagina-Zhulina Anna Stanislavovna
- Kormilitsyna Marina Il'Inichna
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- Lunin Vladimir Glebovich
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- Meshcherjakova Irina Sergeevna
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|
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2022 |
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|
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1995 |
- Gajnullina M.N.
- Dmitriev I.P.
- Dobrikova E.Ju.
- Khromykh A.A.
- Ignat'Ev G.M.
- Pugachev K.V.
- Ageenko V.A.
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- Pletnev A.G.
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|
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