RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA TYPHIMURIUM T10/PKHBC AS PRODUCER OF HEPATITIS B VIRUS CORE ANTIGEN Russian patent published in 2003 - IPC

Abstract RU 2216590 C1

FIELD: biotechnology, genetic engineering. SUBSTANCE: invention proposes the novel recombinant attenuated strain of bacterium Salmonella tryphimurium T10/pKHBc that is obtained by method of genetic transformation of the strain Salmonella typhimurium T10 with plasmid pKHBc. The strain provides constitutive synthesis of HbcAg (core antigen of hepatitis B virus). After administration of the strain to laboratory animals it causes induction of specific anti-VGV antibodies and specific cellular response. The novel strain can be used for construction of live vaccine against hepatitis B. EFFECT: valuable medicinal properties of strain and antigen. 2 dwg, 1 tbl, 2 ex

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RU 2 216 590 C1

Authors

Karpenko L.I.

Veremejko T.A.

Ignat'Ev G.M.

Il'Ichev A.A.

Bojchenko M.N.

Vorob'Ev A.A.

Dates

2003-11-20—Published

2002-02-26—Filed