COMPOUND, PHARMACEUTICAL COMPOSITION, APPLYING, METHOD FOR PROPHYLAXIS AND TREATMENT OF DISEASE Russian patent published in 2005 - IPC

Abstract RU 2256652 C1

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes benzamidine derivatives of the general formula (I): wherein R¹ means hydrogen atom, halogen atom, (C₁-C₆)-alkyl or hydroxyl; R² means hydrogen atom or halogen atom; R³ means (C₁-C₆)-alkyl possibly substituted with hydroxy-group, alkoxycarbonyl-(C₃-C₁₃)-alkylsulfonyl, carboxy-(C₂-C₇)-alkylsulfonyl; each among R⁴ and R⁵ means hydrogen atom, halogen atom, (C₁-C₆)-alkyl possibly substituted with halogen atom, (C₁-C₆)-alkoxy-group, carboxy-group, (C₂-C₇)-alkoxycarbonyl, carbamoyl, mono-(C₂-C₇)-alkylcarbamoyl, di-(C₃-C₁₃)-alkylcarbamoyl; R⁶ means heterocycle or similar group; each among R⁷ and R⁸ means hydrogen atom, (C₁-C₆)-alkyl or similar group; n = 0, 1 or 2, or their pharmacologically acceptable salts, esters or amides. Compounds elicit the excellent inhibitory activity with respect to activated factor X in blood coagulation and useful for prophylaxis or treatment of diseases associated with blood coagulation.

EFFECT: improved method for prophylaxis and treatment, valuable medicinal properties of compound.

26 cl, 2 tbl, 253 ex

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RU 2 256 652 C1

Authors

Fudzimoto Koiti

Tanaka Naoki

Simada Ikuko

Asaj Fumitosi

Dates

2005-07-20—Published

2002-04-03—Filed