METHOD AND DEVICE FOR DIAGNOSTICS AND PHOTODYNAMIC THERAPY OF EYE DISEASE Russian patent published in 2005 - IPC

FIELD: medical equipment.

SUBSTANCE: device has illuminator, microscope provided with video channel, which has video camera for forming color image of tested part of eye and optical transfer system of image of tested part of eye to the video camera, video camera for forming fluorescent image of tested part of eye and image optical transfer system of tested part of eye to the video camera and video information representation system which has one input connected with output of color image forming video camera and the other one - with output of fluorescent image forming video camera of tested part of eye. Device also has laser, adapter which focuses laser radiation to tested part of eye. Radiation wavelength of laser belongs to spectral range of absorption of photosensitizer introduced to object of test. System for optical transferring of image of tested part of eye to video camera for forming fluorescent image of tested part of eye has filters which doesn't transmit optical radiation with wavelengths being equal or shorter than laser radiation wavelength and transmits optical radiation with wavelengths exceeding laser radiation wavelengths. Illuminator and system for optical transfer of tested part of eye to video camera for forming of tested part of eye have filters with values of transmission factors within 400-640 nm spectral range in relation to values of transmission factors at wavelengths being equal or longer then laser radiation wavelength to be no less than 10³. Filter of system for optical transfer of optical image of tested part of eye to video camera for forming fluorescent image of tested part of eye has relation between values of transmission factors at spectral range of fluorescence of photosensitizer and values of transmission factors at spectral range having wavelengths exceeding values of spectral range of fluorescence of photosensitizer to be higher then 10³. Homogenizing beam widening member is mounted at output of adapter for mount it at axis of beam coming out of adaptor and shift in perpendicular to axis of the beam. Method of diagnostics and photodynamic therapy of eye diseases is based upon introduction of photosensitizer to patient's organism, upon having diagnostic test by means of irradiation of tested part of eye by exciting radiation and control of distribution of fluorescence intensity along tested part of eye. As photosensitizer, the compound on the base of hydroxialuminium di-, tri- and tetra sulphophtalocianin is used. Laser wavelength is chosen within 667-672 nm spectral range. Diagnostics is carried out on the base of pattern of distribution of fluorescence intensity at spectral range of 667-672 nm at when illuminating by means of laser radiation. Then the tested part of eye is subject to therapeutic illumination with increased fluorescence intensity by means of laser radiation of the unit. Diagnostics and photodynamic therapy can be conducted during the same treatment.

EFFECT: improved efficiency of treatment; reduced risk of damage of healthy tissues of patient's eye.

11 cl, 6 dwg, 1 tbl, 3 ex