FIELD: biotechnology.
SUBSTANCE: claimed strain is obtained by hybridization of epidemic virus with cold adapted and temperature sensitive virus, which represents attenuation donor and is harmless for adults, and infants of 3-14 years old. Said virus makes it possible to obtain reassortant vaccine strains from new epidemic viruses. Strain is effectively cultivated in germinative hen embryos at 32°C, and has temperature sensitivity and cold adaptation. Reassortant has two genes derived from epidemic virus encoding surface proteins (hemagglutinin and neuroamidinase) and six genes derived from attenuation donor encoding non-glycosilated proteins. Strain has no reactogenicity in relation to adults and infants of 3-14 years old at intranasal application.
EFFECT: strain for living influenza intranasal vaccine with good biological properties and reactogenicity.
3 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| INFLUENZA VIRUS STRAIN FOR LIVING INFLUENZA INTRANASAL VACCINE FOR INFANTS AND ADULTS | 2005 |
|
RU2307161C2 |
| VACCINE STRAIN OF INFLUENZA VIRUS A/17/CALIFORNIA/04/6 (H3N2) AND ATTENUATION DONOR A/LENINGRAD/134/17/K7/57 (H2N2) FOR ITS PREPARING | 2006 |
|
RU2315101C2 |
| INFLUENZA VIRUS A/17/WYOMING/03/8 (H3N2) STRAIN FOR PRODUCTION OF LIVING INFLUENZA INTRANASAL VACCINE FOR INFANTS AND ADULTS | 2004 |
|
RU2285723C2 |
| VACCINE STRAIN OF B/60/FLORIDA/04/181 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2422519C1 |
| VACCINE STRAIN OF B/60/BRISBANE/08/83 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2422517C1 |
| VACCINE STRAIN OF B/60/MALAYSIA/04/898 INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2009 |
|
RU2416639C1 |
| VACCINE STRAIN OF A/17/SOLOMON ISLANDS/06/9 (H1N1) INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2422518C1 |
| VACCINE STRAIN OF A/17/BRISBANE/07/1 (H3N2) INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2416640C1 |
| STRAIN OF INFLUENZA VIRUS, GISK ¦ 147, USED FOR PREPARING INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2006 |
|
RU2319744C2 |
| VACCINE STRAIN OF A/17/BRISBANE/07/28 (H1N1) INFLUENZA VIRUS FOR PREPARING LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN | 2010 |
|
RU2416641C1 |
