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(19)

(11)

2 279 431

(13)

(51)

IPC

C07D413/12(2006-01-01)

A61K31/423(2006-01-01)

A61P25/16(2006-01-01)

A61P25/18(2006-01-01)

(21) (22)

Application

2003106194/04, 2002-02-19

(24)

Start date

2002-02-19

(22)

Actual filing date

2002-02-19

(45)

Published

2006-07-10

(72)

Inventor

Fenstra Rulof V.Ronken EhrikKrjuse Kornelis G.Makkriri Ehndrju S.Van Skharrenburg Gustaf J.M.

(73)

Holder

Solvej Farmas'Jutikals B.V.

DERIVATIVES OF BENZOXAZOLONE, PHARMACEUTICAL COMPOSITION AND TREATMENT METHODS Russian patent published in 2006 - IPC C07D413/12 A61K31/423 A61P25/16 A61P25/18

Abstract RU 2279431 C2

FIELD: organic chemistry, medicine, neurology, pharmacy.

SUBSTANCE: invention relates to new derivatives of phenylpiperazine that are partial agonists of D2 receptors and can be used in treatment of the central nervous system disorders, in particular, Parkinson's disease. Invention describes derivatives of benzoxazolone of the formula (1): wherein R means group of the formula (a) or (b) , and their salts. Also, invention describes a method for preparing compounds of the formula (1), pharmaceutical composition based on compounds of the formula (1), method for treatment of Parkinson's disease and method for treatment of the central nervous system disorders, such as schizophrenia, anxiety state and depression based on compounds of the formula 91). Invention provides preparing new compounds possessing the useful biological properties.

EFFECT: improved methods for treatment, valuable medicinal properties of compounds and pharmaceutical composition.

5 cl, 1 tbl, 2 ex

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RU 2 279 431 C2

Authors

Fenstra Rulof V.

Ronken Ehrik

Krjuse Kornelis G.

Makkriri Ehndrju S.

Van Skharrenburg Gustaf J.M.

Dates

2006-07-10—Published

2002-02-19—Filed