VACCINE AGAINST COLIBACTERIOSIS IN NUTRIAS Russian patent published in 2006 - IPC A61K39/108 A61P31/04 

FIELD: veterinary medicine.

SUBSTANCE: the suggested vaccine as an antigen contains the suspension of cells of pure culture of Escherichia coli agent obtained due to selecting affected organs in dead nutrias from local epizootic focus to prepare the suspension followed by inoculation onto differentially-diagnostic media; then one should isolate pure culture of Escherichia coli agent to be grown in beef-infusion-peptone broth at addition of glucose at the titer being about 5-6 bln. microbial cells/cu. cm followed by inactivation due to introducing formalin and aluminum hydroxide at the following ratio of components, weight%: suspension of cells of pure culture of Escherichia coli agent 83.0-85.5; glucose 1.0-2.0; formalin 1.0-2.0; aluminum hydroxide - the rest. The vaccine is safe, highly immunogenic and stable at storage.

EFFECT: higher efficiency.

5 ex, 1 tbl