METHOD FOR PREPARING VACCINE AGAINST COLIBACTERIOSIS IN NUTRIAS Russian patent published in 2006 - IPC A61K39/108 

FIELD: veterinary medicine.

SUBSTANCE: it is necessary to select affected organs in dead nutrias from local epizootic focus to prepare the suspension followed by inoculation onto differentially-diagnostic media; then one should isolate pure culture of Escherichia coli agent to be grown in beef-infusion-peptone broth at addition of glucose up to 0.2%-concentration at the titer being about 5-6 bln. microbial cells/cu. cm followed by inactivation due to introducing formalin up to 0.5-0.6%-final concentration to be kept at 37° C for about 72-96 h. Then on should add 3%-aluminum hydroxide solution at the quantity of 20% against culture volume to be thoroughly mixed, packed and sealed. The method is simple and enables to obtain a highly efficient vaccine.

EFFECT: higher efficiency.

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