ASSOCIATED VACCINE AGINST SALMONELLOSIS AND COLIBACTERIOSIS Russian patent published in 2007 - IPC A61K39/116 A61K39/112 A61K39/108 A61P31/04 

FIELD: veterinary medicine.

SUBSTANCE: the suggested vaccine as antigens contains the cell suspension of pure culture of salmonellosis agent Salmonella typhimurium and Escherichia coli agent obtained due to selecting affected organs in dead nutrias from local epizootic focus, preparing the suspension and fulfilling inoculation onto differentially-diagnostic media. One should isolate pure cultures and separately grow the cultures in beef-extract broth at addition of glucose at concentration being about 4-5 bln. microbial cells/cu. cm. The vaccine, also, contains formalin and aluminum hydroxide at the following ratio of components, weight%: cell suspension of pure culture of salmonellosis agent Salmonella typhimurium isolated from local epizootic focus, in nutritive medium at the titer of about 4-5 bln. microbial cells/cu. cm 37.0-40.5; cell suspension of pure culture of Escherichia coli agent isolated from local epizootic focus, in nutritive medium at the titer of about 4-5 bln. microbial cells/cu. cm 37.0-40.5; glucose 2.0-1.0, formalin 2.0-1.5; aluminum hydroxide - the rest. The vaccine is of high immunogenic activity, it forms pronounced tense immunity, causes no post-vaccinal complications being stable at storage.

EFFECT: higher efficiency.

5 ex, 1 tbl