METHOD FOR PREPARING DERIVATIVE OF INDOLINOSPIROPYRANE Russian patent published in 2007 - IPC C07D491/107 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of derivatives of indolinospiropyrane of the formula (1): wherein R¹ means (C₁-C₁₈)-alkyl; each among R² and R³ mean independently (C₁-C₄)-alkyl; R⁴ means hydrogen atom, hydroxy-group, trichloromethyl, trifluoromethyl formyl, (C₁-C)-alkyl, halogen atom, (C₁-C₄)-alkoxy-, nitro-group; x = 1 or 2. Method comprises the following steps: (i) synthesis of indoline on polymeric carrier of the formula (III): wherein R¹ means (C₁-C₁₈)-alkyl; each among R² and R means independently (C₁-C₄)-alkyl; (ii) treatment of indoline-carrying polymeric carrier wherein this carrier represents hydroxy-resin at temperature from 50°C to 120°C in inert atmosphere for time from 14 h to 11 days with a derivative of salicylic aldehyde of the formula (VI): wherein R⁴ means hydrogen atom, hydroxy-group, trichloromethyl, trifluoromethyl, formyl, (C₁-C₄)-alkyl, halogen atom, (C₁-C₄)-alkoxy-, nitro-group; x = 1 or 2 to yield indolinospiropyrane compound of the formula (I), and (iii) release of indolinospiropyrane compound of the formula (I). Invention proves synthesis of novel derivatives of indolinospiropyrane possessing photochromic properties.

EFFECT: improved method of synthesis.

8 cl, 28 ex