FIELD: chemistry.
SUBSTANCE: invention relates to novel 1,1'-diaryl-3'-aroyl-4'-hydroxy-1H-spiro[indeno[1,2-b]pyrrol-3,2,-pyrrol]-2,4,5'(1'H)-triones of formula:
where a: Ar stands for 4-MeC6H4, X stands for H, Y stands for H; b Ar stands for 4-Me2C6H3, X stands for Me, Y stands for H; c Ar stands for 4-Me2C6H3, X stands for H, Y stands for H; d: Ar stands for Ph, X stands for H, Y stands for H; e: Ar stands for Ph, X stands for CI, Y stands for Me; f: Ar stands for Ph, X stands for Br, Y stands for Me; g: Ar stands for Ph, X stands for CI, Y stands for OMe, which demonstrate analgesic activity. Compounds are obtained by interaction of 1-aryl-4-aroyl-5-methoxycarbonyl-1H-pyrrol-2,3-dione with 3-amino-1H-inden-1-on in medium of inert aprotic solvent at temperature 110-112°C with further separation of target products.
EFFECT: method improvement.
4 cl, 1 dwg, 1 tbl, 8 ex
| Title |
Year |
Author |
Number |
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2014 |
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- Makhmudov Ramiz Ragibovich
|
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2021 |
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|
RU2763738C1 |
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|
RU2520005C2 |
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2018 |
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|
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2021 |
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|
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2012 |
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|
RU2502738C2 |
| APPLICATION OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYALKYL)-1,3-DIALKYL-2-THIOXO-1,3,6-TRIAZASPIRO[4.4 NON-8-ENE-4,7-DIONES AS AGENTS WITH ANTIMICROBIAL ACTIVITY |
2021 |
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|
RU2763731C1 |
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2023 |
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|
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2022 |
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RU2790379C1 |
