CIRCULATION-OVERLAPPING SOLID-PHASE PREPARATION WITH COVERING BEING OUT OF IMMOBILIZED BINDING PREPARATION Russian patent published in 2007 - IPC A61K9/00 A61K9/16 A61K38/36 A61K38/39 A61K47/48 A61P35/00 A61L31/16 

FIELD: medicine.

SUBSTANCE: the present innovation deals with methods and compositions for targeted supply of circulation -overlapping solid-phase thrombocytes-binding preparations for treating vascularized tumor or hyperplastic tissue. The solid-phase preparation covered except polystyrene with thrombocytes-binding preparation, such as Willebrand's factor, should be purposefully directed towards vascular net-target in vivo, where it binds and activates thrombocytes which, in their turn, bind and activate other thrombocytes. Variant of composition for inducing thrombogenesis in vivo and containing a solid-phase thrombocytes-binding preparation, except polystyrene, could be consisted of the first binding component and the second binding component, where the first binding component has got binding area for binding a solid-phase preparation with a ligand-receptor complex, and not with a ligand or receptor separately, as for the second binding component it has got binding area for thrombocytes. The innovation provides rapid formation of a dense thrombus that leads to overlapping the circulation in the desired area due to thrombocytic fixation towards the surface of a solid-phase preparation along with increasing its sizes and developing a multi-layer structure of activated thrombocytes as a dense matrix.

EFFECT: higher efficiency.

29 cl, 12 ex, 2 tbl