ALPHA-FORM OR BETA-FORM OF CRYSTAL OF ACETANILIDE DERIVATIVE Russian patent published in 2007 - IPC C07D277/20 C07D277/40 C07D277/44 A61K31/426 A61P3/10 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel crystalline forms that can be used as components in preparing a solid pharmaceutical antidiabetic composition and antidiabetic medicinal agent. Invention relates to α-form of crystal and β-form of crystal of (R)-2-(2-aminothiazol-4-yl)-4'-{2-(2-hydroxy-2-phenylethyl)amino)]ethyl}acetanilide. α-Form of crystal shows the heat-absorption peak at 142-146°C in DSC-analysis and main peaks of X-rays powdery diffraction 5.32, 8.08, 15.28, 17.88, 19.04, 20.20, 23.16 and 24.34 in 2θ(°) units, it doesn't show hygroscopicity but possesses stability and therefore can be used as a medicinal agent. β-Form of crystal shows heat-absorbing peaks at 90-110°C and 142-146°C in DSC-analysis and main peaks in X-rays powdery diffraction 9.68, 19.76, 20.72, 22.10 and 23.52, it doesn't show hygroscopicity relatively and useful as an intermediate substance in preparing α-form of crystal also.

EFFECT: valuable properties of crystal.

8 cl, 2 tbl, 9 dwg, 4 ex