MOLECULAR COMPLEX FOR TRANSFECTION OF MAMMALIAN CELLS, CONTAINING PLASMIDE DNA, MODIFIED POLYETHYLENEIMINE, AND LIGAND MOLECULES Russian patent published in 2007 - IPC C12N5/00 C12N15/87 C08G73/00

Abstract RU 2303064 C2

FIELD: molecular biology.

SUBSTANCE: disclosed is molecular transfecting complex (MTC) comprising of plasmide DNA carrying necessary genetic information, polyethyleneimine, modifies with acylhydrazine groups and being capable to form ion complexes with plasmide DNA, ligand molecules for receptor-mediated MTC addressing to certain cell types and providing prolonged MTC circulation in blood. Ligand molecule contains one or more aldehyde groups, whereby such molecules may be attached after DNA-acylhydrazidopolyethyleneimine complex formation. Invention is useful in medicine for gene therapy.

EFFECT: complexes with prolonged storage life.

5 cl, 8 dwg, 10 ex

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RU 2 303 064 C2

Authors

Krivtsov Georgij Georgievich

Fajzuloev Evgenij Bakhtierovich

Dates

2007-07-20—Published

2005-04-06—Filed