BIODEGRADABLE CATIONIC POLYMERS Russian patent published in 2012 - IPC A61K47/48 C08G73/02 A61K48/00

Abstract RU 2451525 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to biodegradable polymers suitable for delivery of biological agents to cells. Proposed is a polymer containing a link with formula (I) where PEI is a link of polyethylenimine with molecular weight less than 600 Daltons; R is a pair of electrons; L is selected from among C₂-C₅₀ carboxialkenyl and residues of fatty acid from C₁₂ to C₁₈; m is an integer from 1 to 30. Additionally proposed is a polymer complex with an oligonucleotide and a method for eukaryote cells transfection using such complex.

EFFECT: proposed polymer is applicable for safe and effective delivery of a small interfering RNA or oligonucleotides to the cell.

16 cl, 2 dwg, 1 tbl, 5 ex

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Authors

Tanaka Jasunobu

Tsao Gehng

Jju Lej

Dates

2012-05-27—Published

2007-04-03—Filed