FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns medicine, in particular to experimental cardiology and pharmacology, and concerns correction of endothelial dysfunction. For this purpose in experiment endothelial dysfunction is modeled to male laboratory rats of Wistar line by intraperitoneal daily injection of the N-nitro-L-arginine of methyl ether in a dose of 25 mg/kg, within 7 days. Simultaneously a Phosphogliv preparation is entered daily intragastrically in a dose 2.2g/kg. The way provides effective correction of endothelial dysfunction at the expense of Phosphogliv ability to raise production and bioavailability of nitrogen oxide.
EFFECT: effective correction of endothelial dysfunction.
1 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH PREPARATION PHOSPHOGLIV LYOPHILIZATE IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY | 2008 |
|
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|
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| METHOD OF PICAMILONUM-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
|
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| METHOD FOR CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF INDAPAMIDE AND RESVERATROL AT L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE | 2005 |
|
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| METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOZARTAN AND RAZVERATROL IN CASES OF LONAME-INDUCED NITROGEN MONOXIDE DEFICIENCY | 2005 |
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RU2306924C1 |
| METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION BY COMBINATION OF ENALAPRIL AND RESVERATROL IN L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE | 2005 |
|
RU2301670C1 |
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RU2306929C1 |
| METHOD OF TADALAFIL-BASED CORRECTION OF ENDOTHELIAL DYSFUNCTION IN L-NAME INDUCED NITRIC OXIDE DEFICIENCY | 2008 |
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RU2364392C1 |
