METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF INDAPAMIDE AND L-ARGININE IN L-NAME-INDUCED NITROGEN DEFICIT Russian patent published in 2007 - IPC A61K31/4045 A61K31/198 A61P9/12 

Abstract RU 2306929 C1

FIELD: medicine, pharmacology.

SUBSTANCE: endothelial dysfunction is modulated in Wistar-line rats by daily intraperitoneal administering of L-nitro-arginine-methyl ester in dose of 25 mg/kg for 7 days and simultaneously combination of indapamide and L-arginine is administered one time per day, wherein indapamide is administered intragastrically in dose of 2 mg/kg and L-arginine is administered intraperitoneally in dose of 200 mg/kg.

EFFECT: method for correction of endothelial dysfunction due to synergistic action of indapamide and L-arginine.

2 tbl, 1 ex

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RU 2 306 929 C1

Authors

Pokrovskij Mikhail Vladimirovich

Kochkarov Vladimir Iskhakovich

Pokrovskaja Tat'Jana Grigor'Evna

Gladchenko Mikhail Petrovich

Artjushkova Elena Borisovna

Novikov Oleg Olegovich

Novikova Marina Jur'Evna

Afanas'Ev Jurij Ivanovich

Zhiljakova Elena Teodorovna

Prokhoda Evgenij Fedorovich

Pashin Evgenij Nikolaevich

Grimova Taisija Aleksandrovna

Denisjuk Tat'Jana Alekseevna

Lazarenko Galina Stepanovna

Korokina Lilija Viktorovna

Gureev Vladimir Vladimirovich

Mikaeljan Pavel Keropovich

Kharchenko Aleksandr Vladimirovich

Chernomortseva Elena Stanislavovna

Gumanova Nadezhda Georgievna

Dates

2007-09-27Published

2005-12-28Filed