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IPC

A61K31/4178(2006-01-01)

A61K31/197(2006-01-01)

A61P9/08(2006-01-01)

A61P9/14(2006-01-01)

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Application

2005140968/14, 2005-12-28

(24)

Start date

2005-12-28

(22)

Actual filing date

2005-12-28

(45)

Published

2007-09-27

(72)

Inventor

Pokrovskij Mikhail VladimirovichKochkarov Vladimir IskhakovichPokrovskaja Tat'Jana Grigor'EvnaGladchenko Mikhail PetrovichArtjushkova Elena BorisovnaNovikov Oleg OlegovichAfanas'Ev Jurij IvanovichZhiljakova Elena TeodorovnaProkhoda Evgenij FedorovichPashin Evgenij NikolaevichTikhova Ljubov' IvanovnaLazarenko Galina StepanovnaZaloznykh Jana IgorevnaKorokina Lilija ViktorovnaAkhmedzjanova Izabella NikolaevnaMuljar Aleksandr GeorgievichMetel'Skaja Viktorija Alekseevna

(73)

Holder

Pokrovskij Mikhail VladimirovichKochkarov Vladimir IskhakovichPokrovskaja Tat'Jana Grigor'EvnaArtjushkova Elena Borisovna

METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF LOSARTAN AND L-ARGININE IN L-NAME-INDUCED NITROGEN DEFICIT Russian patent published in 2007 - IPC A61K31/4178 A61K31/197 A61P9/08 A61P9/14

Abstract RU 2306930 C1

FIELD: medicine, pharmacology.

SUBSTANCE: endothelial dysfunction is modulated in Wistar-line rats by daily intraperitoneal administering of L-nitro-arginine-methyl ester in dose of 25 mg/kg for 7 days and losartan is administered intragastrically in dose of 200 mg/kg one time per day.

EFFECT: method for correction of endothelial dysfunction due to synergistic action of losartan and L-arginine.

2 tbl, 1 ex

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RU 2 306 930 C1

Authors

Pokrovskij Mikhail Vladimirovich

Kochkarov Vladimir Iskhakovich

Pokrovskaja Tat'Jana Grigor'Evna

Gladchenko Mikhail Petrovich

Artjushkova Elena Borisovna

Novikov Oleg Olegovich

Afanas'Ev Jurij Ivanovich

Zhiljakova Elena Teodorovna

Prokhoda Evgenij Fedorovich

Pashin Evgenij Nikolaevich

Tikhova Ljubov' Ivanovna

Lazarenko Galina Stepanovna

Zaloznykh Jana Igorevna

Korokina Lilija Viktorovna

Akhmedzjanova Izabella Nikolaevna

Muljar Aleksandr Georgievich

Metel'Skaja Viktorija Alekseevna

Dates

2007-09-27—Published

2005-12-28—Filed