MEANS OF DIFFERENTIAL DIAGNOSTICS OF BRONCHIAL ASTHMA CLINICO-PATHOGENETIC VARIANTS AND INCIPIENCE OF CHRONIC OBSTRUCTIVE LUNG DISEASE Russian patent published in 2012 - IPC A61B5/08 A61B5/91 A61B5/15 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention refers to medicine particularly to allergology and pulmonology and can be used in differential diagnostics of bronchial asthma (BA) - atopic asthma (AA), asthmatic triad (AT) and incipience of chronic obstructive lung disease (COLD). For this purpose respiratory function is checked of a patient and Tiffeneau index is defined. Then cytokines IL-4 and IL-8 concentration in periferic blood and antioxidant transferrin are defined. Further the mathematical model including the examined indexes is made and complex mathematic performance evaluation. On the first stage the regressive function is calculated according to the formula f _COLD/BA = 4.1609+ a*(-5.787)+b*(-0.062)+c*(0.01308)+d*(-0.1025) where Tiffeneau index (1 - value >70% of the due values, 0 - value <70% of the due values); b content IL-4 (equivalent units); c content IL-8 (equivalent units); d - transferrin content (equivalent units). Then the potential is calculated in respect to according to the formular P _COLD/BA =1/(1+y ^-fCOLD/BA ) where P _COLD/BA is potential COLD occurrence in respect to BA; e=2.718 is the base of the natural logarithm. With P _COLD/BA ≥0.5 the probability of COLD occurrence is higher in respect to BA - in this case COLD is diagnosed. If P _COLD/BA <0.5 the probability of BA occurrence is higher in respect to COLD. In this case pass to the second stage when the regressive function is calculated according to the formula F _AT/AA =-21.847+a*(26.607)+b*(-0.2227)+c*(0.1)+d*(-0.304). After this the probability of AT occurrence in respect to AA is calculated according to the formula P_AT/AA =1/(1+e ^-1AT/AA ) where P_AT/AA is the probability of At occurrence in respect to AA. With P_AT/AA ≥0.5 the probability of AT occurrence is higher in respect to AA then AT is diagnosed. If P P_AT/AA <0.5 the probability of AA occurrence is higher in respect to AT then AA is diagnosed.

EFFECT: means provides timely effective differential diagnostics of bronchial asthma clinico-pathogenetic variants and incipience of COLD for timely pathogenetic treatment of such diseases.

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