FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for synthesis of α-adamantyl-containing derivatives of trimethylbicyclo[2.2.1]heptane-2-one of the general formula: 
wherein R means Ad; R1 means hydrogen atom (H); R2 = R3 means -CH3 (1); R = R3 means H; R1 means -CH3; R2 means Ad (2); R means Ad-Br; R1 means H; R2 = R3 means -CH3 (3) that are potentially biologically active substances. Method involves adding the corresponding derivative of trimethylbicyclo[2.2.1]heptane-2-one to derivative of adamantine wherein 1,3-dehydroadamantane is used as derivative of adamantine, and 1,7,7-trimethylbicyclo[2.2.1]heptane-2-one, 3-bromo-1,7,7-trimethylbicyclo[2.2.1]heptane-2-one and 5,5,6-trimethylbicyclo[2.2.1]heptane-2-one are used derivative of trimethylbicyclo[2.2.1]heptane-2-one, and process is carried out in the mole ratio = 1:1 at temperature 100°C for 5 h. Method provides the claimed compounds with the high yield.
EFFECT: improved method of synthesis.
3 ex
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