FIELD: pharmacology.
SUBSTANCE: invention relates to pharmaceutical composition containing polypeptide: Lys(B3), Glu(B29), human insulin, surfactant or combination of several surfactants, optionally conserving agent or combination of several conserving agents, and optionally isotonic agent, buffer or other auxiliaries, or combination thereof. wherein pharmaceutical composition is zinc-free or zinc-depleted. Disclosed is method for production of such insulin-containing compositions.
EFFECT: insulin compositions of increased stability.
8 cl, 6 ex
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