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2 312 857

(13)

(51)

IPC

C07D209/34(2006-01-01)

C07F9/572(2006-01-01)

A61K31/40(2006-01-01)

A61P9/00(2006-01-01)

A61P9/10(2006-01-01)

(21) (22)

Application

2004131201/04, 2003-03-20

(24)

Start date

2003-03-20

(22)

Actual filing date

2003-03-20

(45)

Published

2007-12-20

(72)

Inventor

Gillman Kevin V.Khevavasam PijasenaShmits Uill'Jam D.Lopez Omar D.Starrett Dzhon E.Povensal Dehvid P.

(73)

Holder

Bristol-Maers Skvibb Kompani

PHOSPHATE DERIVATIVES OF FLUOROOXINDOLES AND METHOD FOR TREATMENT BY THEIR USING Russian patent published in 2007 - IPC C07D209/34 C07F9/572 A61K31/40 A61P9/00 A61P9/10

Abstract RU 2312857 C2

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to group of compound of the formula (I): wherein a wave-like bond means a racemate, (R)-enantiomer or (S)-enantiomer; A represents a linear bond or -(C=O); B represents a linear bond, oxygen or nitrogen atom; m has value 0 or 1; n has value 1, 2 or 3; each among R¹ and R² means independently hydrogen atom or (C₁-C)-alkyl, and if R¹ represents hydrogen atom then R² can represents also -P(O)OR⁵OR⁶; each among R³ and R⁴ means independently hydrogen atom or (C₁-C₄)-alkyl; each among R⁵ and R⁶ means independently hydrogen atom, or its nontoxic pharmaceutically acceptable salt or solvate. Also, invention relates to a method for treatment of diseases showing sensitivity to opening calcium-activated potassium channels. Invention provides synthesis of novel biologically active compounds and a method for treatment of diseases showing sensitivity to opening calcium-activated potassium channels of large conductivity in mammals.

EFFECT: improved method of treatment, valuable medicinal properties of compounds.

9 cl, 1 tbl, 25 ex

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RU 2 312 857 C2

Authors

Gillman Kevin V.

Khevavasam Pijasena

Shmits Uill'Jam D.

Lopez Omar D.

Starrett Dzhon E.

Povensal Dehvid P.

Dates

2007-12-20—Published

2003-03-20—Filed