FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel derivatives of pyridylcyanoguanidine of the formula (I): 
wherein X1 and X2 represent independently a bond, linear or branched hydrocarbon diradical; Y1 and Y2 represent independently a bond or -O-; Y3 represents oxygen atom (O), -O-C(O)-, N(R8) wherein R8 represents hydrogen atom; R1 represents hydrogen atom, linear or branched alkyl or phenyl; R2 represents aryl, heteroaryl or nonaromatic heterocyclic hydrocarbon radical wherein each is substituted optionally with tetrahydropyranyloxy-, di-(C1-C4-alkoxy)phosphinoyloxy- and (C1-C4)-alkoxycarbonylamino-group; R3 represents hydrogen atom, linear, branched or cyclic hydrocarbon radical substituted optionally with one or more amino- carboxy-, alkoxy-groups, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkoxycarbonylamine or nonaromatic nitrogen-containing heterocyclic hydrocarbon radical substituted optionally with (C1-C4)-alkoxycarbonyl, or compound of the formula: 
wherein s represents a whole number from 1 to 10; R6 represents hydrogen or optionally substituted nonaromatic hydrocarbon radical; R7 represents independently hydrogen atom or methyl; R4, R5 and A represent hydrogen atom; Z' represents pharmaceutically acceptable anion, such as chloride, bromide, iodide; m and r represent independently a whole number from 0 to 4; n = 0 or 1. Also, invention relates to compound of the formula (II) given in the invention description, to pharmaceutical composition based on these compounds for preparing a drug used in treatment of proliferative diseases, methods for treatment and using.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
37 cl, 2 tbl, 36 ex
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