PYRROLO[2.1-C][1.4]BENZODIAZEPINES, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2008 - IPC C07D487/04 A61K31/5517 A61P35/00

Abstract RU 2314309 C2

FIELD: organic chemistry, medicine, oncology, pharmacy.

SUBSTANCE: invention describes novel pyrrolo[2.1-c][1.4]benzodiazepines of the general formula (V): wherein R and R₁ represent hydrogen atom (H) and/or hydroxyl (-OH); n means from 3 to 5. Also, invention relates to a method for synthesis of these compounds and a pharmaceutical composition based on thereof. Novel compounds are inhibitors of cancer cells growth and can be used in medicine.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.

21 cl, 2 tbl, 1 dwg, 9 ex

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RU 2 314 309 C2

Authors

Kamal Akhmed

Ramesh Gudzhdzhar

Srinivas Olepu

Ramulu Poddutoori

Dates

2008-01-10—Published

2003-03-31—Filed