METHOD OF DEFINITION BIOLOGICAL ACTIVITY OF DEFIBROTIDE Russian patent published in 2008 - IPC C12Q1/37 C12Q1/56 G01N33/48 

Abstract RU 2323979 C2

FIELD: production methods.

SUBSTANCE: method is based on the capability of defibrotide to increase the fermentation activity of plasmin and foresee the stages: a) making the contact in reactional area defibrotide, plasmin and substrate specific for plasmin which, because of reaction, provides the defined product b) the definition of the amount of obtained product in temporary points.

EFFECT: invention allows to define the biological activity of defibrotide in comparison with standard etalon with height accuracy and big repeatability.

9 cl, 6 dwg, 4 tbl, 1 ex

Similar patents RU2323979C2

Title Year Author Number
METHOD FOR DEFIBROTIDE BIOLOGICAL ACTIVITY DETERMINATION, BASED ON EUGLOBULIN APPLICATION 2012
  • Inoni Terentsio
  • Kumar Vidzhej
  • Islam Kkhalid
RU2627177C2
LIQUID DEFIBROTIDE COMPOSITION FOR TREATMENT AND PREVENTION OF VENOUS OCCLUSIVE DISEASE 2017
  • Inoni Terentsio
  • Kumar Vidzhej
  • Islam Kkhalid
RU2766143C2
METHOD FOR DETERMINING TISSULAR PLASMINOGEN ADJUVANT 2003
  • Ajsina R.B.
  • Bulygin O.Ju.
  • Varfolomeev S.D.
  • Vojushina T.L.
  • Mukhametova L.I.
  • Mamaev A.N.
  • Momot A.P.
RU2252421C1
METHOD FOR IN VITRO DETERMINATION OF ACTIVATION OF PLASMINOGEN WITH BACTERIA 2012
  • Shipko Elena Sergeevna
  • Mishan'Kin Boris Nikolaevich
  • Duvanova Ol'Ga Viktorovna
  • Romanova Ljudmila Vasil'Evna
RU2514662C2
PLASMINOGEN UROKINASE TYPE MODIFIED ACTIVATOR, DNA SEQUENCE, RECOMBINANT PLASMID, STRAIN-PRODUCER, METHOD FOR PREPARING PLASMINOGEN UROKINASE TYPE MODIFIED ACTIVATOR AND PHARMACEUTICAL COMPOSITION ELICITING THROMBOLYTIC EFFECT 2001
  • Gurskij Ja.G.
  • Belogurov A.A.
  • Bibilashvili R.Sh.
  • Grigor'Eva N.V.
  • Del'Ver E.P.
  • Minashkin M.M.
RU2247777C2
METHOD OF PREPARING ENZYME DESTABILASE SHOWING FIBRINOLYTIC, THROMBOLYTIC, ENDO- AND EXO-GAMMA)-LYS-ISOPEPTIDASE AND AMIDOLYTIC ACTIVITY 1994
  • Sverdlov E.D.
  • Baskova I.P.
  • Zavalova L.L.
  • Luk'Janov S.A.
  • Barsova E.V.
  • Bogdanova E.A.
RU2112528C1
FIBRINE-ISOPEPTIDASE 1991
  • Sverdlov Evgenij Davidovich
  • Zavalova Ljudmila L'Vovna
  • Kuzina Elena Vital'Evna
RU2049819C1
METHOD OF DETERMINING PLASMINOGEN AND PLASMIN INHIBITORS LEVELS IN BLOOD PLASMA 1998
  • Stepanov V.M.
  • Vojushina T.L.
  • Teren'Teva E.Ju.
  • Mil'Gotina E.I.
  • Nevedrova O.E.
  • Makarov V.A.
  • Kogan A.E.
RU2121690C1
SOLUBLE FIBRIN MONOMER PREPARATION METHOD 2003
  • Ajsina R.B.
  • Bulygin O.Ju.
  • Mukhametova L.I.
  • Varfolomeev S.D.
  • Mamaev A.N.
  • Momot A.P.
RU2253474C1
METHOD OF EXTRACTION AND PURIFICATION OF RECOMBINANT HUMAN PROUROKINASE M5 2013
  • Tikhonov Roman Vladimirovich
  • Smolova Ksenija Aleksandrovna
  • Kazarov Aleksandr Aleksandrovich
  • Feshin Denis Borisovich
  • Fabrichnyj Igor' Pavlovich
RU2553533C2

RU 2 323 979 C2

Authors

Porta Roberto

Kattaneo Franko

Ferro Laura

Dates

2008-05-10Published

2002-11-27Filed