FIELD: medicine; immunotherapy.
SUBSTANCE: indications for adjuvant immunotherapy of primary and metastatic malignant unresectable liver tumours are determined. For this purpose within surgical process incision biopsy of tumour and healthy liver tissue is performed. Then immediately after operation lymphocytes of tumour tissue, healthy tissue and peripheral blood by markers CD4+, CD8+, CD16+, CD56+ are immunophenotyped. In case lymphocyte marker levels CD4+, CD8+ and NK-cells levels CD16+ and CD56+ are lowered more than 10% for tumour tissue and peripheral blood in comparison with healthy tissue and peripheral blood, postoperative intraportal prolonged introduction of rhoncoleukin is indicated.
EFFECT: provides accurate direct evaluation of local immunity condition; enables to improve treatment results.
12 dwg, 4 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR TREATING THE CASES OF OVARIAN CARCINOMA | 2001 |
|
RU2191586C1 |
| METHOD OF TREATING LUNG CANCER | 2011 |
|
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| METHOD FOR LOCAL-DISTRIBUTED COLON CANCER METASTASIS | 2016 |
|
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| METHOD OF TREATING DISSEMINATED RENAL CARCINOMA | 2009 |
|
RU2409382C1 |
| METHOD OF TREATING ONCOLOGICAL PATIENTS WITH CYTOTOXIC LYMPHOCYTES | 2015 |
|
RU2596505C1 |
| METHOD FOR LIFESPAN EVALUATION IN PATIENTS WITH LOCALLY ADVANCED AND DISSEMINATED RENAL CELL CARCINOMA | 2009 |
|
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| METHOD FOR PREDICTION OF LIFE EXPECTANCY IN PATIENTS WITH METASTATIC TUMORS | 2023 |
|
RU2821659C1 |
| METHOD OF PRODUCING CYTOTOXIC LYMPHOCYTES USING IFN-γ AND TNF-α FOR ADOPTIVE IMMUNOTHERAPY | 2023 |
|
RU2822876C2 |
| METHOD FOR TREATMENT OF REGIONAL UNRESECTABLE PANCREATIC CANCER | 2017 |
|
RU2663468C1 |
| METHOD OF DETERMINING TACTICS OF TREATING LOCALLY ADVANCED AND DISSEMINATED RENAL CELL CARCINOMA | 2009 |
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RU2403056C1 |
