METHOD OF TREATING DISSEMINATED RENAL CARCINOMA Russian patent published in 2011 - IPC A61K38/20 A61K31/675 A61K35/60 A61P35/00 

Abstract RU 2409382 C1

FIELD: medicine.

SUBSTANCE: invention concerns medicine, particularly oncology, and can be applied in treating disseminated renal carcinoma (DRC). A method consists in the preliminary analysis of patient's peripheral blood for absolute concentration of CD4+CD25+Foxp3Treg phenotype cells in mm3. If the value is higher than 100 cells/mm, the patient is prescribed with Ronkoleukin combined with Cyclophosphamide for three weeks with Cyclophosphamide administered in amount 200 mg intramuscularly three times a week every second day, while Ronkoleukin - three times a week in combination with Cyclophosphamide in amount 1 mg intravenously drop-by-drop for two hours, after dissolved in 400 ml of physiologic saline or inhaled in the same dosage, after dissolved in 8-10 ml of physiologic saline. Also, for three weeks, Neovastat is introduced by 30 ml two times a day orally daily. Said therapeutic course is followed with blood analysis for absolute concentration of CD4+CD25+Foxp3Treg phenotype cells every 5 weeks, and if observing the value exceeding 100 cells/mm3, treatment is continued by the suggested regimen same scheme, and the value below 100 cells/mm3 requires the case follow-up.

EFFECT: method allows to improve outcome in the DRC patients, to reduce a number of side effects.

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RU 2 409 382 C1

Authors

Molchanov Oleg Evgen'Evich

Granov Anatolij Mikhajlovich

Dates

2011-01-20Published

2009-08-05Filed