POLYSIALIC ACID DERIVATIVES Russian patent published in 2008 - IPC C08B37/00 A61K47/48 C07K1/107 

FIELD: chemistry; pharmacology.

SUBSTANCE: polysaccharide, in form of polysialic acid, with at least, two sialic acid links, joined to each other at positions 2,8 and/or 2,9, and with a lateral part, linked to at least, one end link, obtained from a sialic acid link, which consists of a functional group chosen from N-maleimide groups, vinylsufonyl groups, N-iodoacetamide groups and orthopyridyl disulphide groups. Polysaccharide is reacted with a hetero bi-functional reagent, with a first functional group, chosen from N-maleimide groups, vinylsufonyl groups, N-iodoacetamide groups and orthopyridyl disulphide groups, and a second functional group, different from the first group, where the stated second functional group reacts with the stated end link, derivative of sialic acid, with formation of a covalent bond and functional polysaccharide, suitable for selective pairing with a thiol group.

EFFECT: reaction with a hetero bi-functional reagent allows for introduction of a side functional group for site-specific bonding to sulfhydryl groups, for example, to side chains of cysteic links in medicines, medication delivery systems, proteins or peptides.

29 cl, 3 dwg, 1 tbl, 4 ex