METHOD OF PRODUCTION OF CAPTURE PHYSIOLOGICALLY ACTIVE SUBSTANCES Russian patent published in 2008 - IPC A61K31/727 A61K38/58 A61P7/02 

FIELD: medicine.

SUBSTANCE: invention refers to biochemistry and medicine, namely to method of production of capture physiologically active substances, specifically blood anticoagulants used for prevention and treatment of thromboses, thrombophlebitis, thromboembolism, thromboembolic complications etc. Method of production of capture physiologically active substances is realised by reaction of physiologically active substance and N- acryloylhygidroxyphthamylide copolymer, of lower critical mixing temperature. Heparin and hirudin are used as physiologically active substance while N-acryloylhygidroxyphthamylide copolymer is copolymer of 1-5% mole N-acryloylhygidroxyphthamylide, 88-98% mole N- isopropylacrylamide or N,N-diethylacrylamide and 1-7 % mole acrylamide of molecular weight 8900-18000.

EFFECT: method provides possibility to produce polymeric derivatives of blood anticoagulants of lowered molecular weight.

24 ex, 3 tbl, 1 dwg