AMINO ALCOHOL DERIVATIVES OR PHOSPHORIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SPECIFIED DERIVATIVES Russian patent published in 2008 - IPC C07D207/335 C07D307/52 C07D333/20 C07F9/655 A61K31/40 A61P37/06 

FIELD: medicine; pharmacology.

SUBSTANCE: invention refers to new compositions of general formula (I): where R¹ and R² mean H; R³ means H; R⁴ means lower alkyl; n is equal to 1-6; X means O; formula group =N-D (where D means H, lower alkyl); Y means ethylene group, ethynylene group, formula group -E-CH₂ - (where E means carbonyl, formula group -CH(OH)-), C₆-C₁₀arylen C₆-C₁₀arylen group substituted with 1-3 substitutes, selected from Group (a) of substitutes; Z means single bond, C₁-C₁₀alkylen group or C₁-C₁₀alkylen group containing oxygen atom in specified carbon chain or on the end of specified carbon chain; R⁵ means H, C₃-C₁₀cycloalkyl group, C₆-C₁₀aryl, C₆-C₁₀aryl group substituted with 1-3 substitutes selected from Group (a) of substitutes; R⁶ and R⁷ are identical or different and represent each H, lower alkyl; Group (a) of substitutes represents group consisting of halogen, lower alkyl group, halogenated lower alkyl group, lower alkoxy group, lower alkylthio group; provided when R⁵ represents H, Z represents branched C₁-C₁₀alkylen group or C₁-C₁₀alkylen group containing oxygen atom in specified carbon chain or on the end of specified carbon chain, or it pharmacologically acceptable salt.

EFFECT: high immunosuppressive activity of compounds and their effective application for pharmaceutical compositions and for methods of preventive rheumatoid arthritis treatment.

51 cl, 13 tbl, 91 ex