APPLICATION OF DERIVATIVES OF SICCINE ACID ETHERS FOR TREATMENT OF DEMENTIA Russian patent published in 2008 - IPC A61K36/898 A61K125/00 A61K31/194 A61K31/222 A61K31/7028 A61P25/28 

FIELD: medicine, pharmacology.

SUBSTANCE: invention relates to application of ethanol extract obtained from dried rhizome of Long-Bracted Green Orchid (Wangla, Coeloglossum viride (L) Hartm. Var. Bracteatum (Wild.) Richter), derivatives of siccine acid ethers of formula: where R₁ and R₄ are selected from -OCH₃, -OH, -OGlu, and R₂ and R₃ are selected from H, -OH, -OGlu, and R₅ is selected from branched and non-branched C_1-6 alkyls, for dementia treatment, particularly, for treatment of Alzheimer-disease and vessel dementia. In addition, invention relates to pharmaceutical compositions including said extract or compounds.

EFFECT: high activity and low toxicity.

14 cl, 4 dwg, 8 tbl, 7 ex