PRODUCTION METHOD OF α -RACEMATE OF 1-(2-PIPERIDYL)-1,2-ETHANDIOL Russian patent published in 2008 - IPC C07D213/30 

Abstract RU 2334740 C1

FIELD: chemistry.

SUBSTANCE: invention refers to production method of α-racemate of 1-(2-piridyl)-1,2-ethandiol: catalytic reducing (1RS)-1-(2-piridyl)-1,2-ethandiol distinctive in that nickel aluminium alloy is used as catalyst, while reduced at atmospheric active hydrogen pressure generated by reaction (1RS)-1-(2-piridyl)-1,2-ethandiol with sodium hydroxide in aqueous medium, resulted in and β-racemates of 1-(2-piperidyl)-1,2-ethandiol and their subsequent diethyl ether fractional crystallisation to produce end product applied as raw product for medical product synthesis, such as Ethoxadrol, Dexoxadrol, Levoxadrol, Dioxadrol.

EFFECT: higher yield and purity of declared connection, as well as reduction of synthesis stages number.

1 cl, 1 ex

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RU 2 334 740 C1

Authors

Novakov Ivan Aleksandrovich

Orlinson Boris Semenovich

Brunilin Roman Vladimirovich

Navrotskij Maksim Borisovich

Eremijchuk Aleksandr Sergeevich

Gordeeva Elena Aleksandrovna

Dates

2008-09-27Published

2007-07-09Filed