FIELD: chemistry.
SUBSTANCE: invention refers to production method of α-racemate of 1-(2-piridyl)-1,2-ethandiol: catalytic reducing (1RS)-1-(2-piridyl)-1,2-ethandiol distinctive in that nickel aluminium alloy is used as catalyst, while reduced at atmospheric active hydrogen pressure generated by reaction (1RS)-1-(2-piridyl)-1,2-ethandiol with sodium hydroxide in aqueous medium, resulted in and β-racemates of 1-(2-piperidyl)-1,2-ethandiol and their subsequent diethyl ether fractional crystallisation to produce end product applied as raw product for medical product synthesis, such as Ethoxadrol, Dexoxadrol, Levoxadrol, Dioxadrol.
EFFECT: higher yield and purity of declared connection, as well as reduction of synthesis stages number.
1 cl, 1 ex
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Authors
Dates
2008-09-27—Published
2007-07-09—Filed