METHOD OF PRODUCING (S)-3-AMINOMETHYL-5-METHYLHEXANOIC ACID Russian patent published in 2018 - IPC C07C227/32 C07C229/08 B01J23/755 

Abstract RU 2643373 C2

FIELD: chemistry.

SUBSTANCE: invention refers to the method of producing (S)-3-(aminomethyl)-5-methylhexanoic acid of the formula I , used in the treatment of some neuropathic diseases, by enantioselective accession of diethylmalonate to 4-methyl-1-nitropentane-1 followed by the reduction and acid hydrolysis of the adduct according to diagram 1

.

The method is characterized by the fact that at the stage of joining the catalyst is a complex of nickel (II) of the formula II with (2S,3S)-N,N'-dibenzylbicyclo [2.2.2]octane-2,3-diamine.

EFFECT: method makes it possible to increase the enantioselectivity of the process.

2 cl, 7 ex

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RU 2 643 373 C2

Authors

Reznikov Aleksandr Nikolaevich

Sibiryakova Anastasiya Eduardovna

Klimochkin Yurij Nikolaevich

Dates

2018-02-01Published

2015-12-04Filed