METHOD OF DIAGNOSTICS AND PROGNOSIS OF SYSTEM INFLAMMATION WITH VERIFICATION OF PHASES AND STAGES Russian patent published in 2008 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: indicators of system inflammatory reaction (SIR) with calculation of integrated indicators SIR - dose values of levels of responsiveness (LR) from 0 to 5, and also signs of system alteration, microthrombogenesis markers, indicators of neuroendocrinal system distress-reaction, signs of multisystem failure (MSF). Express parameters in frequency rate of excess maximum permissible doses (MPD) of normal values of investigated parameters. Thus the acute system inflammation (SI) is characterised as: compensated before-SI phase at LR 1-2, presence of additional SIR markers, low probability of revealing MSF, signs of system alteration and distress-reaction, and also presence of markers of a microthrombogenesis. The subcompensated phase - at LR 2-3 low probability of revealing interleukine - 10 (IL-10) more than 5 MPD, signs of system alteration, distress-reaction, low probability of revealing MSF and high probability of revealing of additional markers SIR. Decompensated phase - at LR 4-5, high probability of revealing IL-10 is more 5 MPD, additional SIR markers, MSF than signs of system alteration, distress-reaction, and also high probability of development of a shock and accuring implications of the disseminated intravascular coagulation; decompensated phase with immunodepression - at LR-2-3, high probability of revealing IL-10 is more 5 MPD, MSF, a shock, signs of system alteration, distress-reaction, high probability of revealing of additional SIR markers, of decompensated disseminated intravascular coagulation. Chronic SI is characterised as: a stage of risk of chronic SI development at LR 0-1, low probability of revealing additional SIR markers and factors of system damage, and also high probability of revealing of chronic destructive diseases; the compensated stage at LR 1-2, low probability of revealing chronic organ failures, low probability of revealing of additional markers SIR, factors of system damage, and also low probability of revealing of markers of a chronic disseminated intravascular coagulation and high probability of revealing of chronic destructive diseases; Unstably compensated stage - at LR 1-3, low probability of development chronic organic failures, is more than low probability of revealing of markers of a chronic disseminated intravascular coagulation, low probability of revealing IL-10 MPD, distresses-reactions, and also high probability of revealing additional SIR markers, chronic destructive diseases and factors of system damage; the subcompensated stage - at LR against hormonal therapy of a basic disease is more 2, against high probability of chronic organ insufficiency, low probability of revealing of increased concentration IL-10, high probability of revealing of additional markers SIR, chronic destructive diseases and factors of system damage.

EFFECT: enhancement of an arsenal of agents for diagnostics and prognosis of system inflammation.

26 tbl, 5 ex