MULTIPLE VERSIONS OF MENINGOCOCCAL PROTEIN NMB 1870 Russian patent published in 2008 - IPC A61K39/95 C07H21/00 A61K35/74 

FIELD: medicine.

SUBSTANCE: according to invention protein NMB 1870 represents effective antigen used for immune response for meningococcus, and it is expressed among all meningococcal serogroup. Forty two various chains NMB 1870 are identified, and they are grouped by three versions. Serum produced for this version is bactericidal in the same group of version, but is inactive for strains expressing the other two other versions, i.e. intra-version, rather than inter-version cross-protection is available. Therefore this invention provides maximum cross-strain efficiency using combinations of various versions NMB 1870. Invention discovers method of mammal immune response induction providing application of compositions on based on various versions NMB 1870. Besides invention presents nucleic acid coding specified versions of protein NMB 1870 (associated chains are specified in chain list). Compositions based on protein NMB 1870 have immunogenic properties for infection, induce formation of bactericidal antibodies, cause immunity for meningococcus and not only for serogroup B meningococcus.

EFFECT: higher efficiency.

32 cl, 37 dwg