IMMOBILISED ANTIBIOTIC DRUG AND METHOD FOR ITS PRODUCTION Russian patent published in 2008 - IPC A61K31/7036 A61K33/08 A61J3/00 A61K47/02 

FIELD: medicine, pharmacology.

SUBSTANCE: immobilised antibiotic drug of common formula B-F-A, where B is base representing calcium phosphate, or hydroxyphosphate (hydrohyapatite), or their mix, F is -P-O- group, implanted on surface of B, A is antibiotic residual, containing non-protonated amino and/or alcohol groups; and method for immobilised antibiotic production, comprising calcium phosphate, or hydroxyphosphate, or their mix, treatment with binding agent, followed by interreaction with antibiotic, containing non-protonated amino and/or alcohol groups; the binding agent used is phosphorus pentachloride; the process being conducted in aprotic solvent.

EFFECT: prolongation of antibiotic washing-off from the surface, antibiotic release in original form, and absence of toxic products resulted from immobilised antibiotic hydrolytic degradation.

5 cl, 7 ex, 8 tbl