METHOD OF PREPARING 1-(ADAMANT-1-YL)ETHYLAMINE AND HOMOLOGUES THEREOF Russian patent published in 2000 - IPC

FIELD: organic synthesis; biologically-active compounds. SUBSTANCE: invention provides novel method for preparing amino derivatives of adamantane with general formula: , wherein either R¹ is hydrogen and R² hydrogen, methyl, or ethyl; or R¹ and R² are both methyl radicals, which compounds are biologically-active substances and those with R¹ hydrogen and R² methyl or ethyl are drug substances. Method consists in reducing nitroalkyladamantanes prepared by interaction of 1,3-dihydroadamantane with nitromethane, nitroethane, 1- nitropropane or 2-nitropropane at molar ratio 1: (10-15) and temperature 100-105 C for 3 h. Reduction of nitro compounds obtained is carried out in presence of hydrochloric acid with 10-fold molar excess of iron cuttings in isopropyl alcohol at 80-85 C for 8 h. EFFECT: increased yield of desired compounds. 4 ex