Show metadata Hide metadata

(19)

(11)

2 346 981

(13)

(51)

IPC

C12N5/00(2006-01-01)

C12N5/08(2006-01-01)

A61K35/407(2006-01-01)

A61P1/16(2006-01-01)

G01N33/00(2006-01-01)

A61K48/00(2006-01-01)

C12P21/02(2006-01-01)

(21) (22)

Application

2005104557/13, 2003-07-17

(24)

Start date

2003-07-17

(22)

Actual filing date

2003-07-17

(45)

Published

2009-02-20

(72)

Inventor

Ladlou Dzhon V.Fert Mark Eh.Brjus Ehndrju T.Rejd Lola M.S'Jusik Robert L. Mladshij

(73)

Holder

Vesta Terap'Jutiks, Ink.

METHOD FOR PRODUCTION OF HUMAN LIVING HEPATIC CELLS, INCLUDING HEPATIC STEM CELLS/PRECURSOR CELLS Russian patent published in 2009 - IPC C12N5/00 C12N5/08 A61K35/407 A61P1/16 G01N33/00 A61K48/00 C12P21/02

Abstract RU 2346981 C2

FIELD: chemistry; biochemistry.

SUBSTANCE: invention relates to biotechnology, in particular to hepatic cells production, and may be used in medical science. From the whole liver or resected part thereof, a cell population enriched with living cells of human liver, including hepatic stem cells/precursor cells, is obtained. Cell population contains functional hepatocytes and biliary cells expressing cytokeratin 19 (CK19), but not expressing albumin, as well as hepatic stem cells/precursor cells 9 to 13 mcm in diameter and expressing EP-CAM, CD 133 markers. Resulting cell population is used for hepatotherapy.

EFFECT: production of living population of hepatic cells sufficiently efficient for regeneration.

60 cl, 16 dwg

Similar patents RU2346981C2

Title	Year	Author	Number
METHOD FOR PREPARING CELLS FOR REPLACEMENT CELL THERAPY OF HEPATIC PATHOLOGY	2012	Petrakova Ol'Ga Sergeevna Kirpichnikov Mikhail Petrovich Ashapkin Vasilij Vasil'Evich Sukhanov Jurij Vladimirovich Vasil'Ev Andrej Valentinovich Terskikh Vasilij Vasil'Evich Suprunenko Elena Aleksandrovna	RU2510276C1
CELLS AS PRECURSORS OF HUMAN LIVER	2000	Rejd Lola M. Kubota Khirosi Moss Nikolas	RU2247565C2
PRIMITIVE AND PROXIMAL STEM HEPATOCYTES	2003	Rejd Lola Moss Nikolas Dzh. Fert Mark Eh. Ladlou Dzhon V. Brjus Ehndrju T.	RU2327479C2
MULTIPOTENT STEM CELLS OF EXTRAHEPATIC BILIARY TRACT AND METHOD FOR RECOVERY THEREOF	2010	Reid Lola M. Wang Yunfang Cardinale Vincenzo Gaudio Eugenio Carpino Guido Alvaro Domeniko Cui Cai-Bin	RU2580246C2
MULTIPOTENT STEM CELLS OF EXTRAHEPATIC BILE DUCTS AND METHODS FOR THEIR ISOLATION	2010	Reid Lola M. Wang Yunfang Cardinale Vincenzo Gaudio Eugenio Carpino Guido Alvaro Domenico Cui Cai-Bin	RU2756584C2
CELL PRODUCT FOR TREATING AND CORRECTING HEPATIC IMPAIRMENT	2012	Petrakova Ol'Ga Sergeevna Vasil'Ev Andrej Valentinovich Terskikh Vasilij Vasil'Evich Sukhanov Jurij Vladimirovich	RU2510833C1
METHOD FOR TRANSPLANTING CELLS FROM DENSE TISSUES	2011	Terner Rejchel Gerber Dejvid Lozojja Osval'Do Rejd Lola M.	RU2574364C2
METHOD FOR TREATING HEPATIC CIRRHOSIS CASES	2005	Kolosov Nikolaj Georgievich Seledtsov Viktor Ivanovich Shpagina Ljubov' Anatol'Evna Velichko Aleksej Janovich Poveshchenko Ol'Ga Vladimirovna	RU2318526C2
LIVER ORGANOID, VERSIONS OF USE THEREOF AND CULTURE METHOD FOR PRODUCTION THEREOF	2011	Uch Ortega Meritksel Klevers Jokhannes Karolus	RU2579995C2
BIOTRANSPLANT, METHOD FOR ITS PREPARING AND METHOD FOR TREATMENT OF CHRONIC HEPATITIS AND LIVER CIRRHOSIS (VARIANTS)	2004	Gol'Dshtejn Dmitrij Vadimovich Makarov Andrej Vital'Evich Fatkhudinov Timur Khajsamudinovich Repin Vadim Sergeevich Shamenkov Dmitrij Alekseevich Rzhaninova Alla Anatol'Evna Saburina Irina Nikolaevna Pulin Andrej Alekseevich Utjashev Igor' Agljamovich Bazhanov Nikolaj Aleksandrovich	RU2272638C1

RU 2 346 981 C2

Authors

Ladlou Dzhon V.

Fert Mark Eh.

Brjus Ehndrju T.

Rejd Lola M.

S'Jusik Robert L. Mladshij

Dates

2009-02-20—Published

2003-07-17—Filed